1 Risk of differentiated thyroid carcinoma and polymorphisms within the susceptibility cancer region 8 q 24
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چکیده
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Grants and fellowships supporting the study: ITT and MIUR sustained the costs of the reagents. AIRC and MIUR sustained the costs of the fellowships. Disclosure statement: The authors have nothing to disclose. Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Abstract Objective: Genome-wide association studies (GWAS) have shown that the 8q24 region harbours multiple independent cancer susceptibility loci, and it was also defined as the " susceptibility cancer region ". Thus, it could be hypothesized that genetic variants within this region could play a role in the risk of differentiated thyroid carcinoma (DTC). Research Design and Methods: Six SNPs within 8q24 were analysed, previously associated with the risk of cancer (i.e. rs6983267, rs1447295, rs10808556, rs7000448, rs13254738, and rs13281615) in a population of 1250 patients affected by DTC and 1250 controls from the Centre and Southern Italy.
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تاریخ انتشار 2013